•Conducted a 16-week lifestyle intervention in 54 East Asians with deep phenotyping

•Lifestyle reshapes muscle transcriptome via mitochondrial and insulin-related pathways

•Hundreds of lifestyle-responsive and dozens of Asian-specific e/sQTLs identified

•e/sQTL colocalization with Asian GWASs reveals 16 metabolic risk gene candidates

The 40S ribosomal subunit recycling complex modulates mitochondrial dynamics and endoplasmic reticulum - mitochondria tethering at mitochondrial fission/fusion hotspots

“Single-cell RNA-seq of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases”